Regio- and Stereoselective C(sp²)-H Acylation of Enamides with Aldehydes via Transition-Metal Free Photoredox Catalysis

Kai Zhao,*^a Xiao-Chen Zhang,^a Ji-Yu Tao,^a Xian-Dan Wu,^a Jia-Xu Wu,^a Wei-Ming Li,^a Tong-Hao Zhu,*^b and Teck-Peng Loh*^{a, c}

^aInstitute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 211816, China.

^bInstitute of Advanced Studies, Taizhou University, 1139 Shifu Avenue, Taizhou 318000, China.

^cDivision of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.

Abstract: A straightforward and efficient C(sp²)–H acylation of enamides with aldehydes via transition-metal free photoredox catalysis is demonstrated. The transformation proceeded smoothly without resorting to expensive and potentially toxic iridium or ruthenium polypyridyl based photocatalysts under mild conditions, furnishing a diverse range of synthetically crucial geometrically-defined β-acylated enamides in a stereoselective and regioselective manner.

Green Chemistry. 2020, 22, 5497-5503. (2019年影响因子:9.480).

论文链接：https://doi.org/10.1039/D0GC01947J